Acetylcholine actions on skeletal muscle

THE CONTEXT

The skeletal muscle response to acetylcholine depends on how it reaches the muscle endplate.

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Iontophoretic application of acetylcholine to the muscle endplate causes contraction of the muscle fibre.

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Intraarterial injection of a high dose can cause twitching and fasciculations.

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Intravenous injection generally produces no skeletal muscle effect because acetylcholine is rapidly hydrolysed.

NEETx

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