The passage describes adverse effects associated with nicotinic acid used for hyperlipidemia and liver toxicity from excessive intake of either niacin form.
Nicotinic acid in hyperlipidemia
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Nicotinic acid has been used to treat hyperlipidemia at doses of approximately 1–6 g/day.
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These doses cause blood-vessel dilation and flushing, along with skin irritation.
Liver toxicity
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Intakes exceeding 500 mg/day of either nicotinic acid or nicotinamide cause liver damage.