Study note
Obstetrics & GynecologyHypertensive Disorders in Pregnancy

Antiangiogenic effects and factor V Leiden in pre-eclampsia

THE CONTEXT
The passage continues the discussion of factors implicated in pre-eclampsia.

Endothelial dysfunction

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The antiangiogenic factor sFit-1 binds vascular endothelial growth factor (VEGF) and placental growth factor (PlGF), causing endothelial cell dysfunction.

Genetic risk

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The factor V Leiden mutation increases the risk of pre-eclampsia.
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