Biochemical, hormonal and oxidative changes in pre-eclampsia
THE CONTEXT
The passage links laboratory abnormalities to disease severity, renal involvement and endothelial damage in pre-eclampsia.
Hematological markers
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The degree of thrombocytopenia reflects the severity of pathology. Fibronectin, D-dimer and thrombin levels are elevated.
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Microangiopathic hemolytic anemia is the hallmark of HELLP syndrome.
Hormonal findings
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The passage notes conflicting evidence about hormonal status, while describing lowered estrogen and progesterone, potentially increased chorionic gonadotropin, and decreased serum HPL.
Renal and biochemical findings
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Serum urea and nonprotein nitrogen remain normal in mild pre-eclampsia but increase in severe disease.
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Blood uric acid rises above the stated normal level of 4 mg/dL. The passage describes uric acid secretion by the distal tubules.