Cerebroselective anticholinesterases and onset of poisoning
THE CONTEXT
The passage concludes the discussion of Alzheimer's disease therapy and introduces the exposure pattern and early manifestations of anticholinesterase poisoning.
Alzheimer's disease therapy
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Rivastigmine, donepezil and galantamine are listed as relatively cerebroselective anticholinesterases commonly used for Alzheimer's disease.
Exposure and sequence of manifestations
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Anticholinesterases are widely available agricultural and household insecticides. Accidental, suicidal and homicidal poisoning are described.
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Local muscarinic manifestations occur immediately at exposure sites, including the skin, eye and gastrointestinal tract.
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Local effects are followed by complex systemic effects arising from muscarinic, nicotinic and central actions.