Study note

Clinical diagnosis of nodular goitre

THE CONTEXT
Nodular goitre usually has a straightforward clinical presentation, although some findings can resemble carcinoma or autoimmune thyroiditis.

Typical presentation

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The patient is usually euthyroid. Thyroid nodules are palpable and often visible, with a smooth surface and usually firm rather than hard consistency.
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The goitre is painless and moves freely on swallowing.

Diagnostic difficulties

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Calcification can produce hardness and irregularity that simulate carcinoma.
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A painful nodule, sudden appearance or rapid enlargement raises suspicion of carcinoma, but is usually due to haemorrhage into a simple nodule.
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Distinguishing nodular goitre from autoimmune thyroiditis may be difficult, and the two conditions frequently coexist.
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