Functions of neuronal nicotinic receptors

THE CONTEXT

The neuronal nicotinic receptor entry describes responses in autonomic ganglia, the adrenal medulla and the central nervous system.

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In autonomic ganglia, depolarization leads to a postganglionic impulse.

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In the adrenal medulla, neuronal nicotinic receptors mediate catecholamine release.

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In the central nervous system, their effects include site-specific excitation or inhibition.

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These receptors have an intrinsic ion channel and a pentameric structure. Each subunit has four transmembrane segments.

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