Study note
Medicine
Cardiology
Hypertrophic cardiomyopathy: structural characteristics
THE CONTEXT
Hypertrophic cardiomyopathy involves inappropriate left ventricular hypertrophy with abnormal myocardial fibre arrangement and fibrosis.
Prevalence and myocardial changes
•
Prevalence:
The condition affects around 1 in 500 people worldwide, with variation between populations.
•
Myocardial changes:
Inappropriate left ventricular hypertrophy occurs with
myocardial fibre malalignment and fibrosis
.
Distribution of hypertrophy
•
Generalised hypertrophy:
Hypertrophy may involve the heart more broadly.
•
Asymmetric septal hypertrophy:
Hypertrophy may be largely confined to the interventricular septum; other regions can also be involved.
•
Apical variant:
Apical hypertrophic cardiomyopathy is common in the Far East.
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