Study note
Obstetrics & GynecologyHypertensive Disorders in Pregnancy

Normal trophoblast invasion and spiral arteriole remodeling

THE CONTEXT
Normal endovascular trophoblast invasion remodels the spiral arterioles of the uteroplacental bed.

Extent and structural effects

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The second wave of trophoblast invasion at 16–18 weeks extends to the myometrial segments.
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The remodeling process replaces the endothelial lining and muscular arterial wall with fibrinoid formation.
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The spiral arterioles become distended, tortuous, and funnel shaped.
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