The readable prose continues the explanation of miotics in glaucoma and describes their adverse effects and other ocular uses. The disrupted comparative table is not used.
Use in glaucoma
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Increased outflow facility lowers intraocular tension in open-angle glaucoma.
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Pilocarpine is the preferred miotic. Its action is rapid and lasts 4–6 hours; instillation every 6–8 hours is required, and intraocular tension may still fluctuate between doses.
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Physostigmine 0.1% is used only to supplement pilocarpine.
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The passage describes miotics as third-choice drugs used as add-on therapy in advanced cases and states that they are effective in aphakic glaucoma.
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Pilocarpine is also used with other drugs in angle-closure glaucoma.
Adverse effects
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Frequent ocular adverse effects include diminished vision, particularly in dim light because of pupillary constriction, spasm of accommodation and brow pain.
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Higher-concentration eye drops may produce systemic effects including nausea, diarrhoea, sweating and bronchospasm.
Other ocular uses
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Miotics can reverse the effects of mydriatics after refraction testing.
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To prevent or break adhesions between the iris and lens or the iris and cornea, a miotic is alternated with a mydriatic. The passage mentions adhesions associated with iritis and corneal ulcer.