Study note
Obstetrics & GynecologyHypertensive Disorders in Pregnancy

Pathogenesis of hypertension in pre-eclampsia

THE CONTEXT
The passage links abnormal placentation to widespread vascular dysfunction underlying hypertension.

Underlying mechanism and distribution

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The basic pathology is endothelial dysfunction and intense vasospasm due to abnormal placentation.
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Almost all vessels are affected, particularly those of the uterus, kidney, placental bed, and brain.
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The agent responsible for endothelial dysfunction and vasospasm has not been precisely isolated.
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