Prostaglandin imbalance in pre-eclampsia

THE CONTEXT

Pre-eclampsia is associated with an imbalance between vasodilator prostaglandin and vasoconstrictor thromboxane.

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There is a relative or absolute deficiency of the vasodilator prostaglandin PGI₂ from the vascular endothelium.

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Platelets show increased synthesis of thromboxane A₂ (TXA₂), a potent vasoconstrictor.

NEETx

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