Study note

Specialised investigations and history in hypertension

THE CONTEXT
All hypertensive patients require limited routine investigations, with additional testing appropriate for younger patients or resistant hypertension.

Selection for further assessment

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Additional investigations are appropriate in patients younger than 40 years or those with resistant hypertension.
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Record family history, exercise, salt intake, smoking and other risk factors.
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A careful history can identify drug-induced or alcohol-induced hypertension and symptoms of secondary causes or complications.
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Paroxysmal headache, palpitation and sweating may suggest phaeochromocytoma.

Cardiovascular and renal investigations

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Chest X-ray can detect cardiomegaly, heart failure and coarctation of the aorta.
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Ambulatory blood pressure recording assesses borderline or white coat hypertension.
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Echocardiography detects or quantifies left ventricular hypertrophy.
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Renal ultrasound assesses possible renal disease, while renal angiography detects or confirms renal artery stenosis.

Endocrine investigations

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Urinary catecholamines are used to detect possible phaeochromocytoma.
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Urinary cortisol and a dexamethasone suppression test are used to detect possible Cushing syndrome.
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Plasma renin activity and aldosterone are used to detect possible primary aldosteronism.
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