Study note

Thyroid histology in hyperthyroidism

THE CONTEXT
Hyperthyroidism changes both the acinar epithelium and the appearance of thyroid colloid.

Normal thyroid

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Normal thyroid acini have a cuboidal epithelial lining and contain homogeneous colloid.

Hyperthyroid thyroid

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The acini show hyperplasia and are lined by high columnar epithelium.
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Many acini are empty; others contain vacuolated colloid with characteristic scalloping adjacent to the thyrocytes.
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