Study note
SurgeryThe thyroid gland

Toxic nodule: autonomy and suppression of surrounding tissue

THE CONTEXT
A toxic nodule is a solitary overactive nodule that may occur within generalised nodularity or represent a true toxic adenoma.

Autonomous activity

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The nodule is autonomous, and its hypertrophy and hyperplasia are not due to TSH-RAb.

Effects on TSH and normal thyroid tissue

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High circulating thyroid hormone levels suppress TSH secretion.
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The normal thyroid tissue surrounding the nodule is suppressed and inactive.
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