Study note
Obstetrics & GynecologyHypertensive Disorders in Pregnancy

Trophoblast invasion of uteroplacental spiral arterioles

THE CONTEXT
Normal placentation involves endovascular trophoblast invasion into the walls of spiral arterioles in the uteroplacental bed.

Timing of trophoblast invasion

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In the first trimester, at 10–12 weeks, endovascular trophoblasts invade up to the decidual segments of the spiral arterioles.
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A second wave of trophoblast invasion occurs in the second trimester, at 16–18 weeks.
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