Trophoblastic antiangiogenic factors in pre-eclampsia
THE CONTEXT
Pre-eclampsia is associated with an imbalance of angiogenic and antiangiogenic proteins in the placental vascular bed.
Overproduced antiangiogenic factors
•
Trophoblastic tissue overproduces two antiangiogenic factors: soluble fms-like tyrosine kinase I, identified in the source as sFit-1, and soluble endoglin.