Study notes

Chemokines and other cytokines in acute inflammation

Complement activation: pathways and convergence on C3

Complement effector functions and membrane attack complex

Complement regulation and diseases caused by regulatory defects

Complement activation, functions, and disease

Other inflammatory mediators: PAF, coagulation receptors, kinins, and neuropeptides

Acute inflammation: morphology and serous exudates

Fibrinous inflammation, purulent inflammation, and abscesses

Morphology of inflammatory exudates, abscesses, and ulcers

Outcomes of acute inflammation and the chronic inflammatory response

Causes and disease associations of chronic inflammation

Chronic inflammation: morphology and outcomes

Macrophages: functions, tissue locations, and origins

Classical and alternative macrophage activation

Macrophage functions and persistence in chronic inflammation

Lymphocytes and macrophage populations in chronic inflammation

T-cell subsets and lymphocyte–macrophage feedback in chronic inflammation

Tertiary lymphoid organs and other cells in chronic inflammation

Granulomatous inflammation: formation and morphology

Evaluation of granulomas and systemic inflammatory responses

Fever, inflammatory leukocytosis, and granulomatous reactions

Tissue reactions in selected granulomatous diseases

Acute-phase proteins and systemic manifestations of inflammation

Septic shock, systemic inflammatory response syndrome, and tissue repair

Proliferative capacity and tissue regeneration

Growth signals and stem cells in tissue regeneration

Tissue regeneration and growth factors in repair

Repair growth factors and the importance of the liver framework

Mechanisms of liver regeneration and repair by scarring

Early stages of skin wound healing and granulation tissue

Scar remodeling, wound union, and angiogenesis

Angiogenesis and early connective tissue deposition in wound healing

Extracellular matrix functions, forms, and contribution to fibrosis

Structural and adhesive proteins of the extracellular matrix

Integrin signaling and fibroblast activity in scar formation

Collagen accumulation, scar remodeling, and matrix degradation

Morphology of healing tissue and factors delaying wound repair

Impaired wound healing and chronic ulcers

Wound dehiscence, excessive scarring, and contractures

Organ fibrosis and the basic inflammatory response