Study note

Exogenous and endogenous regulation of cytokine production

THE CONTEXT

Cytokine production responds to external stimuli as well as internal hormonal and biochemical factors.

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Exogenous stimuli regulating cytokine production include antigens and mitogens.

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Endogenous regulators include neuroendocrine hormonal peptides, with corticosteroids and endorphins given as examples.

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Products of the lipoxygenase and cyclooxygenase pathways also regulate cytokine production as endogenous factors.

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