Study note
MicrobiologyImmune Response

Functions of antibody-mediated and cell-mediated immunity

THE CONTEXT
Antibody-mediated immunity and cell-mediated immunity contribute to host defence and also participate in immune-mediated disease.

Antibody-mediated immunity

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Antibody-mediated immunity provides primary defence against most extracellular bacterial pathogens.
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It helps defend against viruses entering through the respiratory or intestinal tracts and prevents recurrence of virus infections.
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It participates in immediate hypersensitivity of types 1, 2 and 3 and in certain autoimmune diseases.

Cell-mediated immunity

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Cell-mediated immunity protects against fungi, viruses and facultative intracellular bacterial pathogens.
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It participates in homograft rejection and graft-versus-host reaction.
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It provides immunological surveillance and immunity against cancer.
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It mediates delayed, type 4 hypersensitivity and participates in certain autoimmune diseases.
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