Study note

Physical properties and stability of transfer factor

THE CONTEXT
Transfer factor (TF) is a small, dialysable substance with resistance to several forms of treatment.

Molecular and antigenic properties

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TF is dialysable and has a low molecular weight of 2,000–4,000.
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TF is not antigenic.

Resistance, storage and inactivation

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TF resists trypsin, DNase, RNase and freeze-thawing.
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It remains stable for several years at –20°C and in lyophilised form at 4°C.
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Heating to 56°C for 30 minutes inactivates it.
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