T-cell function and antigen-specific immunological tolerance
THE CONTEXT
The target describes T-cell-mediated effects and defines immunological tolerance. Its opening continuation refers to monoclonal antibodies.
Diagnostic and research tools
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Monoclonal antibodies are useful tools for diagnostic and research techniques.
T-cell-mediated immunity
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T lymphocytes are responsible for cell-mediated immunity.
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When a T cell encounters an antigen recognised by its receptors, it releases substances collectively called lymphokines.
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Lymphokines activate macrophages and increase their ability to destroy pathogens.
Immunological tolerance
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Immunological tolerance, or unresponsiveness, occurs when contact with an antigen specifically abolishes the capacity to mount an immune response against that antigen on subsequent administration.