An 18-year-old develops generalised tonic–clonic seizures, absences and morning myoclonus. Which epilepsy syndrome best matches this presentation?
QUESTION 82
An outbreak of meningitis follows drought and dust storms in the sub-Saharan African meningitis belt. Which organism is associated with this pattern?
QUESTION 83
Which virus is specifically associated with Mollaret meningitis?
QUESTION 84
Which adverse effect of carbamazepine increases significantly with age and is particularly important in patients taking diuretics or with heart failure?
QUESTION 85
A patient has neurofibromatosis with schwannomas, little skin involvement, and manifestations largely restricted to the eyes and nervous system. Which gene and chromosome association fits this phenotype?
QUESTION 86
A patient develops abrupt spinal cord dysfunction with lower motor neuron signs at the lesion, upper motor neuron signs below it, and spinothalamic sensory loss with preserved dorsal column sensation. Which diagnosis best fits?
QUESTION 87
Which is one of the three main syndromes of botulism?
QUESTION 88
Which statement correctly describes malignant change in neurofibromatosis-associated tumours?
QUESTION 89
Which sensory symptom is the stated exception to the absence of sensory deficits in botulism?
QUESTION 90
On which chromosome is the gene responsible for neurofibromatosis type 1 located?
QUESTION 91
What anatomical displacement defines a tonsillar cone?
QUESTION 92
MRI in a patient with hydrocephalus shows dilated lateral ventricles and a narrowed aqueduct. Which cause of hydrocephalus is illustrated by these findings?
QUESTION 93
Which investigations are key to distinguishing demyelinating from axonal neuropathies and identifying entrapment neuropathies?
QUESTION 94
In a patient with raised intracranial pressure, which treatment is specifically directed at reducing vasogenic oedema?
QUESTION 95
A patient has raised intracranial pressure caused by hydrocephalus. Which intervention is specifically listed to relieve this cause?
QUESTION 96
An adult develops slowly progressive upper motor neuron features affecting the legs more than the arms, with little sensory loss. Several family members have a similar condition with autosomal dominant inheritance. Which diagnosis best fits?
QUESTION 97
Where are the sensory cell bodies of peripheral nerves situated?
QUESTION 98
Which cardiovascular pattern is included in the CDC clinical features of botulism?
QUESTION 99
A patient requires assessment of spinal instability during flexion and extension. Which investigation is described as useful for this dynamic assessment?
QUESTION 100
Which retinal fibres cross at the optic chiasm, and which visual field do they subserve?
QUESTION 101
What is the predominant effect of brainstem inputs on spinal motor reflex control?
QUESTION 102
Which type of spinal connection controls the more complex reflex actions of limb flexion and extension?
QUESTION 103
Through which lobe do the lower fibres from the lateral geniculate nucleus pass on their way to the primary visual cortex?
QUESTION 104
Where is contrast injected during myelography?
QUESTION 105
Which receptors detect muscle lengthening and provide the afferent input for the stretch reflex?
QUESTION 106
Which spinal investigation provides information about vertebrae and intervertebral discs as well as their effects on the spinal cord and nerve roots?
QUESTION 107
Which cells form the lower motor neurons receiving synapses from pyramidal tract upper motor neurons?
QUESTION 108
At which spinal level do the sympathetic fibres supplying the dilator pupillae emerge?
QUESTION 109
Where does the pyramidal tract decussate before entering the lateral columns of the spinal cord?
QUESTION 110
Where do parasympathetic fibres travelling with the 3rd cranial nerve synapse before supplying the constrictor pupillae?
QUESTION 111
Which tract carries projections from the 6th cranial nerve nucleus to the contralateral 3rd nerve nucleus during conjugate horizontal gaze?
QUESTION 112
Which eye movement allows fusion of images at different distances?
QUESTION 113
Delirium describes dysfunction at which neurological level?
QUESTION 114
Magnetic stimulation measures central conduction times by inducing action potentials at which sites?
QUESTION 115
Distal loss of sensation and/or weakness most likely localises neurological disease to which site?
QUESTION 116
Abrupt, brief, irregular, purposeless involuntary movements affecting different body areas suggest disease in which structure?
QUESTION 117
Which cause of chorea is classified as autoimmune?
QUESTION 118
When catatonia has a neurological cause, what is its most common origin?
QUESTION 119
A patient undergoes nerve conduction studies that demonstrate significant slowing of conduction velocity. Which underlying process does this finding suggest?
QUESTION 120
In nerve conduction studies, what does a recorded potential smaller than expected indicate?